1,2,3,6,7,8-Hexahydrocinnolino[5,4,3-cde]cinnoline
نویسنده
چکیده
The title compound, C(12)H(12)N(4), was synthesized by the reaction of hydrazine hydrate and 9-methyl-3,4,6,7-tetra-hydro-2H-xanthene-1,8(5H,9H)-dione in ethanol. In the crystal, the mol-ecule lies across an inversion centre. The pyridazine rings are coplanar and the C(6) rings adopt envelope conformations.
منابع مشابه
2,2,7,7-Tetramethyl-1,2,3,6,7,8-hexahydrocinnolino[5,4,3-cde]cinnoline
The asymmetric unit of the title compound, C(16)H(20)N(4), contains two half-mol-ecules, which are completed by crystallographic inversion symmetry. The pyridazine rings are conjugated and the cyclo-hexane rings adopt envelope conformations.
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Fused pyridazines (1,2,3,6,7,8-hexahydro-cinnolino[5,4,3-cde]cinnoline, L and its 2,2,7,7-tetramethyl derivative, Me4L) are designed as rigid multidentate ligands for the construction of framework solids. In combination with copper(I) bromide (iodide) they provide excellent structural examples for predictive engineering and the possibilities for further fine-tuning of the framework architecture...
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A new domino reaction for the highly selective synthesis of tetracyclic cinnolino[5,4,3-cde]cinnolines using steric control was described. In this reaction, the use of anthenes with aliphatic groups (R(1)) leads to cinnolino[5,4,3-cde]cinnolines whereas anthenes with aryl groups (R(1)) result in N-amino-1,8-dioxoacridines.
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BACKGROUND The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties. METHODS In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity. RESULTS These derivatives particularly halogen substituted cinnoline derivat...
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In medicinal chemistry nitrogen containing heterocycles are the most important compounds which show various biological activities. The cinnoline are nitrogenous derivatives and found to elicit many pharmacological actions like anti-hypertensive, antithrombotic, antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and antisecretory activity. We planned to synthesis new series of ...
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